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Human: Originally developed in Germany in 1949 by a pharmaceutical company as a cold and appetite suppressant, it was later found to have antidepressant properties. However, after a fatal accident occurred in 1973, its popularity temporarily declined. In 1986, the substance began to spread rapidly among rave partygoers in the Mediterranean region, and by 1987, it had become popular among British ravers. Another similar substance is MDA (3,4-methylene-dioxy-amphetamine), which is structurally similar to MDMA. Both substances are known as "entactogens," meaning they increase empathy or feeling of connection with others. However, they affect different neurotransmitter systems: MDA blocks the reabsorption and stimulates the release of norepinephrine, while MDMA affects serotonin release. MDA was first synthesized and initially used more frequently than MDMA due to its lower toxicity. The effects of pure MDMA are characterized by extreme feelings of calmness, comfort, happiness, and self-confidence. However, since ecstasy is often mixed with other substances like caffeine during the manufacturing process, it can have unpredictable effects or side effects. Many people mix it with heroin and caffeine to stay up all night dancing. These feelings of calmness and happiness are due to increased serotonin release in the brain, but they can also lead to depression lasting for several days in some individuals. Others may feel more energetic and alert instead. Since serotonin is limited, taking ecstasy too frequently (more than once a month) can reduce its effectiveness significantly.