Trypsin

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Trypsin is a serine protease discovered in the digestive systems of many vertebrates, where it breaks down proteins through hydrolysis. Trypsin cuts peptide chains mainly at the carboxyl side of amino acids lysine or arginine, except when either one is followed by proline. This enzyme plays a crucial role in numerous biotechnological processes. The process of using trypsin is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to be trypsinized. Trypsin was first identified by Wilhelm Kühne in 1876. A 3D model of the protein in cartoon form with catalytic residues shown as spheres can be found in the STL file. This model is based on the Protein Data Bank entry 4I8H: http://www.pdb.org/pdb/explore/explore.do?pdbId=4i8h This model was created using VMD software available at http://www.ks.uiuc.edu/Research/vmd/.