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Disinfectant A disinfectant, also known as an antiseptic, is a chemical substance used to destroy disease-causing microorganisms on surfaces or in liquid solutions. It can be applied to objects like door handles and countertops, or used in medical procedures to clean equipment and prevent infections. The term "antiseptique" in French is equivalent to "disinfectant" in English, highlighting their shared purpose of eliminating germs and promoting hygiene.