Small Molecule | Pazopanib | PubChem CID10113978

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Pazopanib is a potent pyrimidine compound that boasts a unique chemical structure featuring a 5-(pyrimidin-2-yl)amino-2-methylbenzenesulfonamide group, precisely substituted at position 4 with an innovative (2,3-dimethylindazol-6-yl)(methyl)amino moiety. This remarkable compound is utilized in its hydrochloride salt form to effectively treat kidney cancer, showcasing its impressive antineoplastic properties as a tyrosine kinase inhibitor and vascular endothelial growth factor receptor antagonist. Furthermore, pazopanib's role as an angiogenesis modulating agent highlights its potential to disrupt the complex processes underlying tumor growth. As a member of the indazoles family, pazopanib also falls under the broader categories of aminopyrimidine and sulfonamide compounds. It is worth noting that pazopanib exists in conjugate base form as a pazopanib(1+). Download from NIH 3D Print Exchange: https://3dprint.nih.gov/discover/3DPX-010120