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Serotonin 5-HT1B Receptor and ergotamine

Serotonin 5-HT1B Receptor and ergotamine

sketchfab

The serotonin 5-HT1B receptor is a crucial inhibitory presynaptic receptor that tightly controls the release of neurotransmitters, making it an ideal target for the anti-migraine medication Ergotamine (ERG). This model reveals five pivotal interactions to support and strengthen the binding between the 5-HT1B receptor and ERG, incorporating anchoring, hydrogen bonding, affinity, and specificity.

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