SARS-CoV-2 Spike Protein Molecular Structure

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Molecular structure of the SARS-CoV-2 spike protein reveals a trimer made up of three identical molecules in a closed conformation. The model was constructed using ChimeraX from electron microscopy data stored in the Protein Data Bank (PDB ID 7DF3). DOI: 10.2210/pdb7DF3/pdb & https://www.cgl.ucsf.edu/chimerax/ SARS-CoV-2 trimeric spike glycoprotein conformational dynamics in complex with receptor ACE2 are revealed by cryo-EM according to a study led by Xu, C., Wang, Y., Liu, C., Zhang, C., Han, W., Hong, X., Wang, Y., Hong, Q., Wang, S., Zhao, Q., Wang, Y., Yang, Y., Chen, K., Zheng, W., Kong, L., Wang, F., Zuo, Q., Huang, Z., Cong, Y. (2020) Sci Adv. PubMed: 33277323 DOI: 10.1126/sciadv.abe5575