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Myotilin F-actin Tropomyosin

Myotilin F-actin Tropomyosin

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Tandem models of myotilin's Ig domains bound to F-actin superimposed over the cryo-EM structures of cardiac tropomyosin bound to F-actin in blocked (magenta ribbons, PDB: 5NOG), closed (cyan ribbons, PDB: 5NOL), and open (green ribbons, PDB: 5NOJ) structural states are presented. doi:10.1073/pnas.1700868114 links actin residues found in cross-links with N- and C-terminal regions flanking myotilin's Ig domains to orange residues.

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