Multilayer Microfluidic Structures

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This paper presents a multilayer fluidic structure replication, consisting of at least four layers, utilizing 3D printable PDMS casting molds and molding tray. The authors demonstrate the expansion of microfluidics into three-dimensional space through digital design and improving additive manufacturing technology resolution and materials. The replicated device (Figure 5) is detailed in the supporting information; however, other innovative devices are also presented. Mold printing was done using a 3D Systems ProJet 3000 binder jetting type printer, but alternative fabrication methods include stereolithography (e.g., Form 2, MiiCraft), material jetting (e.g., Stratasys), and selective laser sintering (Form Fuse). Each layer mold is 20 x 20 x 5 mm, while the molds' dimensions are 52 x 52 x 15 mm. The layers consist of PDMS casts (Sylgard 184) and use VisiJet epoxy EX200 with VisiJet wax support material S100 for mold printing on a 3D Systems ProJet 3000 printer. The inspiration behind this comes from Glick, Lin et al.'s research on multilayer microfluidic structures via 3D-printed transfer molding and bonding, available at https://www.nature.com/articles/micronano201663. The accompanying folder includes millimeter-dimensioned files in STL, IGES/IGS format for easy import.