MF70 Head spindle

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Human Spindle Coupling System The human spindle coupling system is a complex process that plays a crucial role in cell division and chromosome segregation during mitosis. It consists of a dynamic microtubule array, known as the kinetochore, which attaches to the sister chromatids at specific regions called centromeres. At the onset of mitosis, the chromosomes condense into compact structures with paired sister chromatids held together by cohesin proteins. The kinetochore forms on each sister chromatid, and microtubules from opposite spindle poles extend towards these kinetochores. The human spindle coupling system is a highly regulated process that ensures accurate segregation of genetic material during cell division. Misregulation of this process can lead to chromosomal abnormalities, such as aneuploidy or gene amplification, which are associated with various diseases and cancers.