LOV1 Domain Phototropin

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This blue-light-sensitive LOV1 domain was modeled after the PDB entry 2z6c and fine-tuned visually within VMD software. As a vital component of the Phototropin protein, this particular LOV1 is responsible for detecting changes in blue light, specifically isolated from Arabidopsis thaliana. This print showcases only the A chain of the LOV1 homodimer, which forms an asymmetrical alignment with the B chain through face-to-face association facilitated by a disulfide bridge and other chemical bonds. The nucleotides that comprise the active site are depicted in CPK, binding to a flavin mononucleotide (FMN) molecule that absorbs blue light energy. In general, the LOV1 domain plays a crucial role in facilitating dimerization of Phototropin1 and Phototropin2 proteins and regulating their sensitivity to blue-light activation signals.