Insulin receptor kinase / IRS2 KRLB peptide

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Protein Data Bank: https://www.rcsb.org/structure/3bu3 IUPHAR: http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=321 Insulin receptor substrates 1 and 2, key adaptor proteins, play a crucial role in mediating the metabolic and mitogenic effects of insulin and insulin-like growth factor 1. In this structure, IRS2 binds to the kinase active site with Tyr628 poised for phosphorylation. Although Tyr628 was indeed phosphorylated by the insulin receptor, its turnover rate was remarkably poor, leading to significant kinase inhibition. Our research clearly shows that the KRLB region functions to restrict tyrosine phosphorylation of IRS2.