
Human proteasome 20S core particle
thingiverse
This is the structure of the human 26S proteasome's core particle based on Huang et al.'s published research in Nature Structural & Molecular Biology (23, 778-785, 2016, DOI:10.1038/nsmb.3273).\nThe PDB file representing the researchers' determined structure was edited to remove the regulatory subunits and the surface rendered using Chimera, then exported as an STL file.\nPrint Settings\nPrinter:\tORD Solutions RoVa3D\nRafts:\tYes\nSupports:\tYes\nResolution:\t0.2 mm\nInfill:\t40%\nNotes:\nThe model was printed with ABS plastic.\nPost-Printing\nThe raft and supports were removed, then the model was polished using acetone vapour.\nHow I Designed This\nBased on PDB file 5GJR from the RCSB protein data bank (www.rcsb.org).\nOverview and Background\nCell Biology class transverse sections through proteasome core particles used to illustrate protein recycling mechanisms in cells.\nLesson Plan and Activity\nThe model was used after a lecture introduction to protein quality control, followed by research paper analysis on protein recycling regulation and its relationship to diseases like Parkinson's.\nReferences\nAn atomic structure of the human 26S proteasome.\tXiuliang Huang, Bai Luan, Jianping Wu & Yigong Shi\tNature Structural & Molecular Biology 23, 778-785 (2016), DOI:10.1038/nsmb.3273
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