GATA-1 bound to FOG and DNA

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GATA-1, a pivotal transcription factor, tightly regulates the expression of genes essential for the development of red blood cells and platelets. FOG, a key co-regulatory protein, establishes a crucial binding interaction with GATA-1's N-finger region. This model elucidates how specific mutations in GATA-1 disrupt its ability to bind to FOG or DNA, providing molecular insights into the underlying mechanisms driving this phenomenon.