EGFR in complex with inhibitor AFN941

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The human epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a crucial role in controlling the proliferation, differentiation, and motility of epidermal cells. This virtual tour takes you through the EGFR kinase domain in complex with inhibitor AFN941 (PDB code 2ITW), highlighting how interactions can be disrupted by other point mutations. Presented by experts 470391833 and 470419218. Context: Cancer researchers Yun, C-H, Boggon, TJ, Li, Y, Woo, MS, Greulich, H, Meyerson, M & Eck, MJ discovered in a groundbreaking study that lung cancer-derived EGFR mutants and inhibitor complexes can be activated by specific mechanisms. Their findings were published in the prestigious journal Cancer Cell in 2007, providing valuable insights into differential inhibitor sensitivity.