DPP-4 peptidase

thingiverse

Dipeptidyl peptidase-4 (DPP-4), an enzyme present on the surface of almost every human cell, cleaves GLP-1 hormone released by intestinal cells upon eating. This inactivates GLP-1, which stimulates insulin release from the pancreas and inhibits glucagon release (raising blood glucose levels). Incretins like GLP-1 maintain blood sugar regulation; however, their effects must be limited. DPP-4 inhibitors, currently being developed for type-2 diabetes treatment, prolong incretin action by blocking DPP-4 enzyme activity. The complete DPP-4 structure requires support and post-print cleaning, while the split model is easier to clean but requires gluing. GLP-1, a small model needing supports, can be printed quickly with high resolution. Printing details include 0.3mm layer height, supports, and 2 interface layers on a Reprappro Mendel Mono using PLA filament in Slic3r software.