67kDa Glutamic Acid Decarboxylase - PDB ID 2OKJ
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The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67) reveals a dynamic catalytic loop regulating GABA production from glutamic acid. Researchers Fenalti, Law, Buckle, Langendorf, Tuck, Rosado, Faux, Mahmood, Hampe, Banga, Wilce, Schmidberger, Rossjohn, El-Kabbani, Pike, Smith, Mackay, Rowley, and Whisstock identify key mechanisms in GAD67's enzymatic activity. Published in Nature Structural & Molecular Biology in 2007 (Volume 14, Issue 3, pp. 280-286), this study is a significant contribution to understanding the molecular basis of neurological disorders. The research findings are documented under PubMed ID 17384644 and accessible through the Protein Data Bank with structure ID 2okj at www.rcsb.org.
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