3D Print: Insulin receptor

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This model is tailored for 3D printing and comes equipped with structural supports that enhance its overall performance. PBD: https://www.rcsb.org/structure/3bu3 IUPHAR: http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=321 Insulin receptor substrates one and two, IRS1 and -2, play a crucial role as adaptor proteins in mediating the metabolic and mitogenic effects of insulin and insulin-like growth factor 1. Within this structure, the segment of IRS2 is bound to the kinase active site with Tyr628 positioned for phosphorylation. Although Tyr628 was indeed phosphorylated by the insulin receptor, its catalytic turnover proved to be poor, resulting in significant kinase inhibition. Our research indicates that the KRLB region functions to limit tyrosine phosphorylation of IRS2.